SrasV1, Main, Exploration, bibRecord, 004478

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Identifieur interne : 004478 ( Main/Exploration ); précédent : 004477; suivant : 004479

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Auteurs : Linqi Zhany [États-Unis, République populaire de Chine] ; FENGWEN ZHANG [États-Unis] ; WENJIE YU [États-Unis] ; TIAN HE [États-Unis] ; JIAN YU [États-Unis] ; Christopher E. Yi [États-Unis] ; LEI BA [États-Unis] ; WENHUI LI [États-Unis] ; Michael Farzan [États-Unis] ; ZHIWEI CHEN [États-Unis] ; Kwok-Yune Yuen [Hong Kong] ; David Ho [États-Unis]

Source :

Journal of medical virology [ 0146-6615 ] ; 2006.

RBID : Pascal:06-0256888

Descripteurs français

Pascal (Inist)
- Virus syndrome respiratoire aigu sévère, Immunité humorale, Réponse immune, Pronostic, Anticorps neutralisant, Développement maladie, Vaccin, Infection, Syndrome respiratoire aigu sévère.
Wicri :
- topic : Vaccin.

English descriptors

KwdEn :
- Disease development, Humoral immunity, Immune response, Infection, Neutralizing antibody, Prognosis, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Vaccine.

Abstract

Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000501
to stream PascalFrancis, to step Curation: 000489
to stream PascalFrancis, to step Checkpoint: 000507
to stream Main, to step Merge: 004708
to stream Main, to step Curation: 004478

Le document en format XML

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<front><div type="abstract" xml:lang="en">Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Hong Kong</li>
<li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>État de New York</li>
</region>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Zhany, Linqi" sort="Zhany, Linqi" uniqKey="Zhany L" first="Linqi" last="Zhany">Linqi Zhany</name>
</region>
<name sortKey="Farzan, Michael" sort="Farzan, Michael" uniqKey="Farzan M" first="Michael" last="Farzan">Michael Farzan</name>
<name sortKey="Fengwen Zhang" sort="Fengwen Zhang" uniqKey="Fengwen Zhang" last="Fengwen Zhang">FENGWEN ZHANG</name>
<name sortKey="Ho, David" sort="Ho, David" uniqKey="Ho D" first="David" last="Ho">David Ho</name>
<name sortKey="Jian Yu" sort="Jian Yu" uniqKey="Jian Yu" last="Jian Yu">JIAN YU</name>
<name sortKey="Lei Ba" sort="Lei Ba" uniqKey="Lei Ba" last="Lei Ba">LEI BA</name>
<name sortKey="Tian He" sort="Tian He" uniqKey="Tian He" last="Tian He">TIAN HE</name>
<name sortKey="Wenhui Li" sort="Wenhui Li" uniqKey="Wenhui Li" last="Wenhui Li">WENHUI LI</name>
<name sortKey="Wenjie Yu" sort="Wenjie Yu" uniqKey="Wenjie Yu" last="Wenjie Yu">WENJIE YU</name>
<name sortKey="Yi, Christopher E" sort="Yi, Christopher E" uniqKey="Yi C" first="Christopher E." last="Yi">Christopher E. Yi</name>
<name sortKey="Zhiwei Chen" sort="Zhiwei Chen" uniqKey="Zhiwei Chen" last="Zhiwei Chen">ZHIWEI CHEN</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Zhany, Linqi" sort="Zhany, Linqi" uniqKey="Zhany L" first="Linqi" last="Zhany">Linqi Zhany</name>
</noRegion>
</country>
<country name="Hong Kong"><noRegion><name sortKey="Yuen, Kwok Yune" sort="Yuen, Kwok Yune" uniqKey="Yuen K" first="Kwok-Yune" last="Yuen">Kwok-Yune Yuen</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

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